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A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

1 May 2003

Abstract excerpt

Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency, reduced fertility, and an elevated risk of cancer. To investigate the mechanism of this disease, we isolated from human HeLa extracts three complexes containing the helicase defective in BS, BLM. Interestingly, one of the complexes, termed BRAFT, also contains five of the Fanconi anemia (FA) complementation group proteins (FA...

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PMID: 12724401
DOI: 10.1128/mcb.23.10.3417-3426.2003

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