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Article

Tyrosinase maturation and oligomerization in the endoplasmic reticulum require a melanocyte-specific factor.

The Journal of biological chemistry - 11 Jul 2003

Francis Edwin, Wang Ning, Parag Hadas, Halaban Ruth, Hebert Daniel N

Abstract excerpt

Tyrosinase is a glycoprotein responsible for the synthesis of melanin in melanocytes. A large number of mutations have been identified in tyrosinase, with many leading to its misfolding, endoplasmic reticulum (ER) retention, and degradation. Here we describe the folding and maturation of human tyrosinase (TYR) using an in vitro translation system coupled with ER-derived microsomes or with semipermeabilized cells,...

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Source

Identifiers

PMID: 12724309
DOI: 10.1074/jbc.M303411200

Genes

TYR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tyrosinase maturation and oligomerization in the endoplasmic reticulum require a melanocyte-specific factor.PMID 12724309Read ↗

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