Article
The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells.
Human reproduction (Oxford, England) - 1 Jul 2006
Ober C, Billstrand C, Kuldanek S, Tan Z
Abstract excerpt
BACKGROUND: HLA-G is a non-classical HLA with important immunomodulatory roles in pregnancy. A polymorphism in the promoter region, -725G, was previously associated with sporadic miscarriage in women who were unselected with respect to reproductive history. In this study, the transcription levels of different HLA-G promoter haplotypes were examined to determine whether the miscarriage-associated -725G allele...
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