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Article

[TNF-alpha PC-1 gene polymorphisms and pre-diabetes quantitative features in the Polish population].

Przeglad lekarski - 1 Jan 2002

Wanic Krzysztof, Małecki Maciej, Klupa Tomasz, Witek Przemysław, Kozek Elzbieta, Sieradzki Jacek

Abstract excerpt

BACKGROUND: Genetics and environmental factors play a role in the pathogenesis of the complex disease, type 2 diabetes mellitus. Two major pathophysiological defects coexist in this disease: impairment of insulin secretion by beta-cells and decreased insulin sensitivity in peripheral tissues. The aim of the study was to examine whether two polymorphisms: the -308 G/A substitution in the promoter region of...

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PMID: 12715715

Genes

TNF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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