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Article

GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast.

The Journal of biological chemistry - 27 Jun 2003

Umemura Mariko, Okamoto Michiyo, Nakayama Ken-ichi, Sagane Koji, Tsukahara Kappei, Hata Katsura, Jigami Yoshifumi

Abstract excerpt

Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in all eukaryotes. In yeast, GPI mediates cross-linking of cell wall mannoproteins to beta1,6-glucan. We reported previously that the GWT1 gene product is a target of the novel anti-fungal compound, 1-[4-butylbenzyl]isoquinoline, that inhibits cell wall localization of GPI-anchored...

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Source

Identifiers

PMID: 12714589
DOI: 10.1074/jbc.M301044200

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast.PMID 12714589Read ↗

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