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Article

The Gup1 homologue of Trypanosoma brucei is a GPI glycosylphosphatidylinositol remodelase.

Molecular microbiology - 1 Jan 2008

Jaquenoud Malika, Pagac Martin, Signorell Aita, Benghezal Mohammed, Jelk Jennifer, Bütikofer Peter, Conzelmann Andreas

Abstract excerpt

Glycosylphosphatidylinositol (GPI) lipids of Trypanosoma brucei undergo lipid remodelling, whereby longer fatty acids on the glycerol are replaced by myristate (C14:0). A similar process occurs on GPI proteins of Saccharomyces cerevisiae where Per1p first deacylates, Gup1p subsequently reacylates the anchor lipid, thus replacing a shorter fatty acid by C26:0. Heterologous expression of the GUP1 homologue of T....

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Source

Identifiers

PMID: 18036137
DOI: 10.1111/j.1365-2958.2007.06043.x

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Gup1 homologue of Trypanosoma brucei is a GPI glycosylphosphatidylinositol remodelase.PMID 18036137Read ↗

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.Semantic proximity Read ↗

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The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei.Semantic proximity Read ↗

Alternative lipid remodelling pathways for glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae.Semantic proximity Read ↗

Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.Semantic proximity Read ↗

The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.Semantic proximity Read ↗

Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.Semantic proximity Read ↗

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