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Article

The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer

14 Mar 2003

Abstract excerpt

Etoposide (VP16) is a potent inducer of DNA double-strand breaks (DSBs) and is efficiently used in small cell lung cancer (SCLC) therapy. However, acquired VP16 resistance remains an important barrier to effective treatment. To understand the underlying mechanisms for VP16 resistance in SCLC, we investigated DSB repair and cellular VP16 sensitivity of SCLC cells. VP16 sensitivity and RAD51, DNA-PK(cs),...

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PMID: 12712436
DOI: 10.1002/ijc.11106

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