Article
Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.
British journal of cancer - 1 Nov 1994
Smith P J, Souès S, Gottlieb T, Falk S J, Watson J V, Osborne R J, Bleehen N M
Abstract excerpt
As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cancer (SCLC) cell populations during protracted VP-16 exposure. Cytometric methods were used...
Topics
- Bromodeoxyuridine
- Carcinoma, Small Cell
- Cell Cycle
- DNA Damage
- DNA Topoisomerases, Type II
- Etoposide
- Flow Cytometry
- G1 Phase
- Genes, p53
- Humans
- Kinetics
- Lung Neoplasms
- Mutation
- S Phase
- Tumor Cells, Cultured