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Article

Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.

British journal of cancer - 1 Nov 1994

Smith P J, Souès S, Gottlieb T, Falk S J, Watson J V, Osborne R J, Bleehen N M

Abstract excerpt

As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cancer (SCLC) cell populations during protracted VP-16 exposure. Cytometric methods were used to analyse changes in target enzyme availability and cell cycle progression in a SCLC cell line, mutant for the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7947097
DOI: 10.1038/bjc.1994.420
PMCID: PMC2033529

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Source receipt: pubmed, retrieved 7 Sept 2026.

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