Article
Altered substrate selectivity of PKC-eta pseudosubstrate site mutants.
FEBS letters - 23 Aug 1993
Dekker L V, McIntyre P, Parker P J
Abstract excerpt
Three protein kinase C (PKC)-eta mutants were constructed in which the whole or part of the pseudosubstrate site was replaced with corresponding parts of the PKC-alpha pseudosubstrate site. The resulting chimaeric kinases were compared with wild-type PKC-eta in their ability to phosphorylate a PKC-eta peptide substrate or histone. Changes in the pseudosubstrate site of PKC-eta are accompanied by changes in...
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