Article
Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis.
Archives of dermatological research - 1 Apr 2003
Kim Tai-Gyu, Pyo Chul-Woo, Hur Sung-Suk, Kim Yang-Kyum, Hwang Ha-Young, Youn Jai-Il, Kim Tae-Yoon
Abstract excerpt
To evaluate the association of TNF-alpha (TNFA) and TNF-beta (TNFB) polymorphisms with psoriasis in the Korean population, we investigated TNF-alpha -238 and -308 promoter region and TNF-beta NcoI polymorphism using PCR-RFLP in 103 Korean psoriasis patients and 125 normal controls. The carriage and allele frequencies of TNFB*2 were significantly increased in patients with psoriasis compared with normal controls....
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