Article
Lack of association between the promoter polymorphisms at positions -308 and -238 of the tumor necrosis factor alpha gene and psoriasis vulgaris in Japanese patients.
Dermatology (Basel, Switzerland) - 1 Jan 2003
Tsunemi Yuichiro, Nishibu Akiko, Saeki Hidehisa, Oyama Noritaka, Nakamura Koichiro, Kishimoto Megumi, Mitsui Hiroshi, Tada Yayoi, Torii Hideshi, Komine Mayumi, Asahina Akihiko, Kaneko Fumio, Tamaki Kunihiko
Abstract excerpt
BACKGROUND: Psoriasis features an increased level and activity of tumor necrosis factor alpha (TNF-alpha). The TNF-alpha gene has single nucleotide polymorphisms (SNPs) at positions -308 (-308G>A) and -238 (-238G>A) in the promoter region, and the -238G>A SNP has been reported to be associated with psoriasis vulgaris (PV) and psoriatic arthritis in Caucasians. OBJECTIVE: To examine whether these SNPs are...
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