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Article

Transgenic mouse with human mutant p53 expression in the prostate epithelium.

The Prostate - 15 Sept 2004

Elgavish Ada, Wood Philip A, Pinkert Carl A, Eltoum Isam-Eldin, Cartee Todd, Wilbanks John, Mentor-Marcel Roycelynn, Tian Liqun, Scroggins Samuel E

Abstract excerpt

BACKGROUND: Apoptosis is disrupted in prostate tumor cells, conferring a survival advantage. p53 is a nuclear protein believed to regulate cancer progression, in part by inducing apoptosis. To test this possibility in future studies, the objective of the present study was to generate a transgenic mouse model expressing mutant p53 in the prostate (PR). METHODS: Transgene incorporation was tested using Southern...

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PMID: 15287091
DOI: 10.1002/pros.20071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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