Article
Genotypic differences in ethanol sensitivity in two tests of motor incoordination.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Oct 2003
Crabbe John C, Metten Pamela, Yu Chia-Hua, Schlumbohm Jason P, Cameron Andy J, Wahlsten Douglas
Abstract excerpt
Motor incoordination is frequently used as a behavioral index of intoxication by drugs that depress the central nervous system. Two tasks that have been used to assay incoordination in mice, the balance beam and the grid test, were evaluated to optimize aspects of apparatus and testing procedures for studying genetic differences. Mice of eight inbred strains were given one of several doses of ethanol or saline...
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