An analysis of the genetics of alcohol intoxication in inbred mice.

doi:10.1016/j.neubiorev.2004.08.002

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Article

An analysis of the genetics of alcohol intoxication in inbred mice.

Neuroscience and biobehavioral reviews - 1 Jan 2005

Crabbe John C, Metten Pamela, Cameron Andy J, Wahlsten Douglas

Abstract excerpt

We compared the behaviors of eight inbred mouse strains across 18 variables, using 11 behavioral assays, and gave ethanol (EtOH) as an intoxicant. Genetic influences on behavior and sensitivity to EtOH were pronounced, but strain sensitivities were generally only modestly correlated across tasks. Certain well-correlated clusters of responses suggested that some genes affect similar neurobiological substrates. No...

Topics

Alcoholic Intoxication
Animals
Behavior, Animal
Central Nervous System Depressants
Disease Models, Animal
Ethanol
Genetic Predisposition to Disease
Genetics, Behavioral
Mice
Mice, Inbred Strains
Motor Activity
Phenotype
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 15642621
DOI: 10.1016/j.neubiorev.2004.08.002

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