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Article

Unusual misregulation of RNA splicing caused by insertion of a transposable element into the T (Brachyury) locus.

BMC genomics - 17 Apr 2003

Goldin Sarah N, Papaioannou Virginia E

Abstract excerpt

BACKGROUND: The TWis mutant allele of the Brachyury, or T, gene was created by insertion of an endogenous retrovirus-like early transposon (ETn) element into the exon 7 splice donor consensus sequence of the 8 exon T locus. While the developmental consequences of this disruption have been well characterized, the molecular consequences have not been previously investigated, and it has been assumed that the...

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Identifiers

PMID: 12702217
DOI: 10.1186/1471-2164-4-14
PMCID: PMC155784

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