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Article

Transposable element insertions respecify alternative exon splicing in three Drosophila myosin heavy chain mutants.

Genetics - 1 Nov 1998

Davis M B, Dietz J, Standiford D M, Emerson C P

Abstract excerpt

Insertions of transposable elements into the myosin heavy chain (Mhc) locus disrupt the regulation of alternative pre-mRNA splicing for multi-alternative exons in the Mhc2, Mhc3, and Mhc4 mutants in Drosophila. Sequence and expression analyses show that each inserted element introduces a strong polyadenylation signal that defines novel terminal exons, which are then differentially recognized by the alternative...

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Identifiers

PMID: 9799262
DOI: 10.1093/genetics/150.3.1105
PMCID: PMC1460390

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