ENU-induced allele of brachyury (Tkt1) exhibits a developmental lethal phenotype similar to the original brachyury (T) mutation.

doi:10.1002/jez.1402540307

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Article

ENU-induced allele of brachyury (Tkt1) exhibits a developmental lethal phenotype similar to the original brachyury (T) mutation.

The Journal of experimental zoology - 1 Jun 1990

Justice M J, Bode V C

Abstract excerpt

New alleles of brachyury (Tkt1, Tkt4) were induced in the mouse complete tw5 haplotype by ethylnitrosourea (ENU). Like the original brachyury (T) mutation, the new alleles cause a short-tailed phenotype in heterozygotes, and interact with the t complex tail interaction factor (tct) in trans to cause phenotypically tailless mice. Because ENU is mainly a point mutagen, it is important to determine that the new...

Topics

Alleles
Animals
Chi-Square Distribution
Chromosome Mapping
Crosses, Genetic
Embryo, Mammalian
Ethylnitrosourea
Female
Genes, Lethal
Genes, Recessive
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Mutant Strains

Mutagens

Mutation

Phenotype

Recombination, Genetic

Source

Open in PubMed

Identifiers

PMID: 2345346
DOI: 10.1002/jez.1402540307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2345346-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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