Article
A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor.
The Journal of clinical investigation - 1 Apr 2003
Nedvetzki Shlomo, Golan Itshak, Assayag Nathalie, Gonen Erez, Caspi Dan, Gladnikoff Micha, Yayon Avner, Naor David
Abstract excerpt
Synovial fluid cells from joints of rheumatoid arthritis (RA) patients express a novel variant of CD44 (designated CD44vRA), encoding an extra trinucleotide (CAG) transcribed from intronic sequences flanking a variant exon. The CD44vRA mutant was detected in 23 out of 30 RA patients. CD44-negative Namalwa cells transfected with CD44vRA cDNA or with CD44v3-v10 (CD44vRA wild type) cDNA bound FGF-2 to an equal...
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