Article
Participation in normal immune responses of a metastasis-inducing splice variant of CD44.
Science (New York, N.Y.) - 31 Jul 1992
Arch R, Wirth K, Hofmann M, Ponta H, Matzku S, Herrlich P, Zöller M
Abstract excerpt
A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic...
Topics
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- Base Sequence
- Blotting, Northern
- DNA
- Genetic Variation
- Lymphocyte Activation
- Molecular Sequence Data
- Neoplasm Metastasis
- Rats