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Blood spotlight on Langerhans cell histiocytosis

4 Jun 2014

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare disease affecting people of any age, with widely variable clinical manifestations and different outcomes. The precise chain of events driving lesional granuloma formation has remained elusive for many years. There is evidence for inherited predisposition to and derangement of apoptosis and inflammation in lesional dendritic cells. Recently somatic BRAF(V600E) mutation...

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PMID: 24894775
DOI: 10.1182/blood-2014-02-556407

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