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Article

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604

2 Dec 2014

Abstract excerpt

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children and other high-risk populations. RSV nucleoprotein (N) is essential for virus assembly and replication as part of the viral ribonucleoprotein (RNP) complex. RSV604 was a putative N inhibitor in phase 2 clinical trials whose molecular mechanism of action (MoA) was not well understood. This study...

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PMID: 25451060
DOI: 10.1128/aac.04119-14

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