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Article

Infertility in female mice with an oocyte-specific knockout of GPI-anchored proteins

1 May 2003

Abstract excerpt

Glycosylphosphatidylinositol-anchored proteins on the egg surface have been proposed to play a role in gamete fusion on the basis of in vitro experiments. We tested this hypothesis by asking if oocyte GPI-anchored proteins are required for fertilization in vivo. Oocyte-specific knockout mice were created using the Cre/loxP system to delete a portion of the Pig-a gene, which encodes an enzyme involved in GPI...

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PMID: 12692150
DOI: 10.1242/jcs.00430

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