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Article

The Sarcomeric Spring Protein Titin: Biophysical Properties, Molecular Mechanisms, and Genetic Mutations Associated with Heart Failure and Cardiomyopathy.

Current cardiology reports - 16 Jul 2021

Eldemire Ramone, Tharp Charles A, Taylor Matthew R G, Sbaizero Orfeo, Mestroni Luisa

Abstract excerpt

PURPOSE OF REVIEW: The giant protein titin forms the "elastic" filament of the sarcomere, essential for the mechanical compliance of the heart muscle. Titin serves a biological spring, and therefore structural modifications of titin affect function of the myocardium and are associated with heart failure and cardiomyopathy. RECENT FINDINGS: In this review, we discuss the current understanding of titin's...

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Source

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Identifiers

PMID: 34269900
DOI: 10.1007/s11886-021-01550-y
PMCID: PMC8522185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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