Article
Lipoprotein lipase gene sequencing and plasma lipid profile.
Journal of lipid research - 1 Jan 2014
Pirim Dilek, Wang Xingbin, Radwan Zaheda H, Niemsiri Vipavee, Hokanson John E, Hamman Richard F, Barmada M Michael, Demirci F Yesim, Kamboh M Ilyas
Abstract excerpt
Lipoprotein lipase (LPL) plays a crucial role in lipid metabolism by hydrolyzing triglyceride (TG)-rich particles and affecting HDL cholesterol (HDL-C) levels. In this study, the entire LPL gene plus flanking regions were resequenced in individuals with extreme HDL-C/TG levels (n = 95), selected from a population-based sample of 623 US non-Hispanic White (NHW) individuals. A total of 176 sequencing variants were...
Topics
- Adult
- Aged
- Case-Control Studies
- Cholesterol, HDL
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Genetic Association Studies
- Haplotypes
- Humans
- Linkage Disequilibrium
- Lipoprotein Lipase
- Male
- Middle Aged