Article
Lipoprotein lipase gene sequencing and plasma lipid profile.
Journal of lipid research - 1 Jan 2014
Pirim Dilek, Wang Xingbin, Radwan Zaheda H, Niemsiri Vipavee, Hokanson John E, Hamman Richard F, Barmada M Michael, Demirci F Yesim, Kamboh M Ilyas
Abstract excerpt
Lipoprotein lipase (LPL) plays a crucial role in lipid metabolism by hydrolyzing triglyceride (TG)-rich particles and affecting HDL cholesterol (HDL-C) levels. In this study, the entire LPL gene plus flanking regions were resequenced in individuals with extreme HDL-C/TG levels (n = 95), selected from a population-based sample of 623 US non-Hispanic White (NHW) individuals. A total of 176 sequencing variants were...
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