Article
No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET.
Synapse (New York, N.Y.) - 15 Jun 2003
Shioe Kunihiko, Ichimiya Tetsuya, Suhara Tetsuya, Takano Akihiro, Sudo Yasuhiko, Yasuno Fumihiko, Hirano Masami, Shinohara Manabu, Kagami Masato, Okubo Yoshiro, Nankai Masahiro, Kanba Shigenobu
Abstract excerpt
The human serotonin transporter (5-HTT) gene has a polymorphism in the 5'-flanking promoter region that is called the serotonin transporter gene-linked polymorphic region (5-HTTLPR). In lymphoblast cell lines, the promoter activity of the 5-HTT gene is dependent on 5-HTTLPR allelic variants. The...
Topics
- Adult
- Alleles
- Brain
- Carbon Radioisotopes
- Carrier Proteins
- Genotype
- Humans
- Isoquinolines
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- Polymorphism, Genetic
- Promoter Regions, Genetic