Article
Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt.
Neuroscience letters - 13 Feb 2009
Segal Jair, Schenkel Laila Cigana, Oliveira Marcela Herbstrith de, Salum Giovanni Abrahão, Bau Claiton Henrique Dotto, Manfro Gisele Gus, Leistner-Segal Sandra
Abstract excerpt
A polymorphism in the serotonin transporter gene (5-HTTLPR) is being extensively studied for association with suicidal behavior. A new allelic variant within the 5-HTTLPR polymorphism was described but it has not been thoroughly analyzed in the recent literature. The SNP functional analysis demonstrated that the A variant of the L allele (L(A)) produces high levels of mRNA and that the G variant (L(G)) is...
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