Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upstream and downstream targets of RUNX proteins.

Journal of cellular biochemistry - 1 May 2003

Otto Florian, Lübbert Michael, Stock Michael

Abstract excerpt

In recent years, the in vivo role of the three members of the RUNX family of transcription factors has in part been elucidated. While Runx1 is essential for mature haematopoiesis and Runx2 for osteochondrogenesis, Runx3 has a function in the nervous system. Translocations and mutations affecting the RUNX1 gene are clearly implicated in leukemogenesis whereas recent data suggest that changed expression levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chondrogenesis
Share to Core Binding Factor Alpha 1 Subunit
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 3 Subunit

Share to Hematopoiesis

Share to Neoplasm Proteins

Share to Osteogenesis

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 12682904
DOI: 10.1002/jcb.10491

Genes

RUNX1
RUNX2
RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upstream and downstream targets of RUNX proteins.PMID 12682904Read ↗

Perspectives on RUNX genes: an update.Semantic proximity Read ↗

RUNX family: Regulation and diversification of roles through interacting proteins.Semantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

RUNX Family as a Promising Biomarker and a Therapeutic Target in Bone Cancers: A Review on Its Molecular Mechanism(s) behind TumorigenesisSemantic proximity Read ↗

Pan-cancer landscape of the RUNX protein family reveals their potential as carcinogenic biomarkers and the mechanisms underlying their actionSemantic proximity Read ↗

The RUNX Family, a Novel Multifaceted Guardian of the GenomeSemantic proximity Read ↗

Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML FactorsSemantic proximity Read ↗

Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation.Semantic proximity Read ↗

Runx2, a multifunctional transcription factor in skeletal development.Semantic proximity Read ↗

The RUNX Family of Proteins, DNA Repair, and CancerSemantic proximity Read ↗

Runx2: A master organizer of gene transcription in developing and maturing osteoblastsSemantic proximity Read ↗

Control of RUNX2 isoform expression: The role of promoters and enhancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.