Article
Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.
Neurology - 8 Apr 2003
van der Walt J M, Martin E R, Scott W K, Zhang F, Nance M A, Watts R L, Hubble J P, Haines J L, Koller W C, Lyons K, Pahwa R, Stern M B, Colcher A, Hiner B C, Jankovic J, Ondo W G, Allen F H, Goetz C G, Small G W, Mastaglia F, Roses A D, Stajich J M, Booze M W, Fujiwara K, Gibson R A, Middleton L T, Scott B L, Pericak-Vance M A, Vance J M
Abstract excerpt
Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or...
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