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Article

Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003

Li Lei, Haynes M Page, Bender Jeffrey R

Abstract excerpt

Estrogen receptor (ER) alpha variants have been identified in an array of nonendothelial cells. We previously demonstrated that estrogen rapidly induces nitric oxide release via a phosphatidylinositol 3-kinase/Akt/endothelial nitric-oxide synthase (eNOS) pathway in EA.hy926 cells (immortalized human endothelial cells), which express a 46-kDa ER. We now confirm that, due to alternative splicing, the 46-kDa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12682286
DOI: 10.1073/pnas.0831079100
PMCID: PMC153637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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