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Article

Splice isoform estrogen receptors as integral transmembrane proteins.

Molecular biology of the cell - 1 Nov 2011

Kim Kyung Hee, Toomre Derek, Bender Jeffrey R

Abstract excerpt

In addition to enhancing or repressing transcription, steroid hormone receptors rapidly transduce kinase activation signals. On ligand engagement, an N-terminus-truncated splice isoform of estrogen receptor (ER) α, ER46, triggers membrane-initiated signals, resulting in endothelial nitric oxide synthase (eNOS) activation and endothelial NO production. The orientation of ER46 at the plasma membrane is incompletely...

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Identifiers

PMID: 21937726
DOI: 10.1091/mbc.E11-05-0416
PMCID: PMC3216666

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