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Article

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.

The Journal of cell biology - 14 Apr 2003

Xia Chun-Hong, Roberts Elizabeth A, Her Lu-Shiun, Liu Xinran, Williams David S, Cleveland Don W, Goldstein Lawrence S B

Abstract excerpt

To test the hypothesis that fast anterograde molecular motor proteins power the slow axonal transport of neurofilaments (NFs), we used homologous recombination to generate mice lacking the neuronal-specific conventional kinesin heavy chain, KIF5A. Because null KIF5A mutants die immediately after birth, a synapsin-promoted Cre-recombinase transgene was used to direct inactivation of KIF5A in neurons postnatally....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12682084
DOI: 10.1083/jcb.200301026
PMCID: PMC2172877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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