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Article

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.

The Journal of general physiology - 1 Sept 2010

Bai Yonghong, Li Min, Hwang Tzyh-Chang

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is the only member of the adenosine triphosphate-binding cassette (ABC) transporter superfamily that functions as a chloride channel. Previous work has suggested that the external side of the sixth transmembrane segment (TM6) plays an important role in governing chloride permeation, but the function of the internal side remains relatively obscure. Here,...

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Identifiers

PMID: 20805575
DOI: 10.1085/jgp.201010480
PMCID: PMC2931150

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.PMID 20805575Read ↗

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.Semantic proximity Read ↗

Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Semantic proximity Read ↗

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore.Semantic proximity Read ↗

Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Semantic proximity Read ↗

Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.Semantic proximity Read ↗

Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties.Semantic proximity Read ↗

The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.Semantic proximity Read ↗

Novel pore-lining residues in CFTR that govern permeation and open-channel block.Semantic proximity Read ↗

Structural identification of a selectivity filter in CFTRSemantic proximity Read ↗

Variable reactivity of an engineered cysteine at position 338 in cystic fibrosis transmembrane conductance regulator reflects different chemical states of the thiol.Semantic proximity Read ↗

Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR.Semantic proximity Read ↗

CFTR transmembrane segments are impaired in their conformational adaptability by a pathogenic loop mutation and dynamically stabilized by Lumacaftor.Semantic proximity Read ↗

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