Article
Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003
Giannelli Gianluigi, Fransvea Emilia, Bergamini Carlo, Marinosci Felice, Antonaci Salvatore
Abstract excerpt
PURPOSE: The purpose of this work was to study the expression of the extracellular matrix protein laminin-5 (Ln-5) in hepatocellular carcinoma (HCC), which is the fifth most frequent cancer and the third most common cause of tumor-related death in the world. The occurrence of metastasis is the main problem in HCC patients. Ln-5 is an extracellular matrix component that promotes adhesion and migration; it is...
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