Article
Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003
Giannelli Gianluigi, Fransvea Emilia, Bergamini Carlo, Marinosci Felice, Antonaci Salvatore
Abstract excerpt
PURPOSE: The purpose of this work was to study the expression of the extracellular matrix protein laminin-5 (Ln-5) in hepatocellular carcinoma (HCC), which is the fifth most frequent cancer and the third most common cause of tumor-related death in the world. The occurrence of metastasis is the main problem in HCC patients. Ln-5 is an extracellular matrix component that promotes adhesion and migration; it is...
Topics
- Biomarkers, Tumor
- Blotting, Northern
- Carcinoma, Hepatocellular
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- Humans
- Immunohistochemistry
- Liver
- Liver Neoplasms
- Neoplasm Metastasis
- Phenotype
- Prognosis
- RNA, Messenger