Article
Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity.
Blood - 1 Aug 2003
Rollinson Sara, Levene Adam P, Mensah Fiona K, Roddam Philippa L, Allan James M, Diss Tim C, Roman Eve, Jack Andrew, MacLennan Kenneth, Dixon Michael F, Morgan Gareth J
Abstract excerpt
Gastric marginal zone lymphoma (GMZL) is strongly associated with Helicobacter pylori infection, which induces a chronic inflammatory response. Inflammation can result in DNA damage related to its severity, the cellular antioxidant capacity, and the integrity of DNA repair mechanisms. Interleukin-1 (IL-1) polymorphisms have been shown to be important mediators of inflammation, while glutathione S-transferase GST...
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