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Article

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

Cancer cell - 1 Jun 2005

Martín Alberto, Odajima Junko, Hunt Sarah L, Dubus Pierre, Ortega Sagrario, Malumbres Marcos, Barbacid Mariano

Abstract excerpt

p27(Kip1) and p21(Cip1) are thought to suppress tumor growth and prevent cell cycle progression by inhibiting Cdk2-cyclin E/A kinases. Since Cdk2 is dispensable for mitotic cell division, we analyzed the activity of these inhibitors in Cdk2-deficient cells. Ectopic expression of p27(Kip1) or p21(...

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Source

Identifiers

PMID: 15950907
DOI: 10.1016/j.ccr.2005.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15950907-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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