Article
Characterization of unusual escape variants of hepatitis B virus isolated from a hepatitis B surface antigen-negative subject.
Journal of virology - 1 Sept 1998
Grethe S, Monazahian M, Böhme I, Thomssen R
Abstract excerpt
Hepatitis B virus DNA was extracted from serial serum samples of a hepatitis B surface antigen-negative patient with antibodies to the core protein as the only marker of an infection with hepatitis B virus. This patient showed no symptoms of hepatic injury. Sequencing of the amplified viral DNA demonstrated multiple amino acid changes clustering in surface-exposed regions of the surface protein. Synthesis and...
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