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Article

A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging.

The Journal of biological chemistry - 13 Jun 2003

Senoo-Matsuda Nanami, Hartman Philip S, Akatsuka Akira, Yoshimura Shinichi, Ishii Naoaki

Abstract excerpt

The mev-1(kn1) mutation of Caenorhabditis elegans is in Cyt-1, which encodes a subunit of succinate-coenzyme Q oxidoreductase in the mitochondrial electron transport chain. Mutants are hypersensitive to oxidative stress and age precociously in part because of increased superoxide anion production. Here, we show that mev-1 mutants are defective in succinate-coenzyme Q oxidoreductase, possess ultrastructural...

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PMID: 12672828
DOI: 10.1074/jbc.M211377200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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