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Article

Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.

The Journal of biological chemistry - 13 Jun 2003

Inaba Toshimori, Matsuda Morihiro, Shimamura Mitsuru, Takei Norihide, Terasaka Naoki, Ando Yosuke, Yasumo Hiroaki, Koishi Ryuta, Makishima Makoto, Shimomura Iichiro

Abstract excerpt

The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly low plasma triglyceride levels. In KK/San mice, genetic analysis identified a mutation in the gene encoding angiopoietinlike protein 3 (Angptl3), a liver-specific secretory protein, which had suppressive effect on lipoprotein lipase activity. In the current study, LXR ligands augmented Angptl3 mRNA expression and...

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PMID: 12672813
DOI: 10.1074/jbc.M213202200

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FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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