Article
Integrin β3 Deficiency Results in Hypertriglyceridemia via Disrupting LPL (Lipoprotein Lipase) Secretion.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2020
Xiao Bing, Mao Jianhua, Sun Boyang, Zhang Wei, Wang Yun, Wang Pengran, Ruan Zheng, Xi Wenda, Li Huiyuan, Zhou Jingyi, Lu Yide, Ding Qiulan, Wang Xuefeng, Liu Jingqiu, Yan Jinsong, Luo Cheng, Shi Xiaofeng, Yang Renchi, Xi Xiaodong
Abstract excerpt
OBJECTIVE: Integrin β3 is implicated in numerous biological processes such as its relevance to blood triglyceride, yet whether β3 deficiency affects this metabolic process remains unknown. Approach and Results: We showed that the Chinese patients with β3-deficient Glanzmann thrombasthenia had a 2-fold higher serum triglyceride level together with a lower serum LPL (lipoprotein lipase) level than those with an...
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