Article
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
The Journal of rheumatology - 1 Apr 2003
Hukkanen Mika, Platts Louise A M, Haralambous Sylva, Ainola Mari, Konttinen Yrjö T, Kollias George, Polak Julia M
Abstract excerpt
OBJECTIVE: Transgenic mice that express human tumor necrosis factor-alpha (Tg197 h-TNF-alpha) develop polyarthritis at 3 to 4 weeks of age leading to severe joint destruction at 8 to 10 weeks of age. Studies have suggested that inducible nitric oxide synthase (iNOS) activity can modulate the progression of arthritis. We investigated the induction of iNOS together with argininosuccinate synthase (AS) and GTP...
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