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Article

Disparate expression of the <i>PTEN</i> gene: a novel finding in B‐cell chronic lymphocytic leukaemia (B‐CLL)

1 Apr 2003

Abstract excerpt

One fifth of B-cell chronic lymphocytic leukaemia (B-CLL) patients exhibit loss of heterozygosity (LOH) at 10q23.3, the site of the tumour suppressor PTEN. Microsatellite markers mapped complete LOH to 10q23.3 in 2/41 B-CLL (5%) and allelic imbalances in 6/41 (15%). No PTEN gene mutations were found. PTEN protein expression was not detected in 11 B-CLL (28%), and was reduced in eight patients (20%). LOH or...

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PMID: 12670337
DOI: 10.1046/j.1365-2141.2003.04227.x

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Disparate expression of the <i>PTEN</i> gene: a novel finding in B‐cell chronic lymphocytic leukaemia (B‐CLL)PMID 12670337Read ↗

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