Article
In-depth mutation and SNP discovery using DHPLC gene scanning.
Current opinion in drug discovery & development - 1 Mar 2003
Lilleberg Stan L
Abstract excerpt
Denaturing high-performance liquid chromatography (DHPLC) is a new technology used in the discovery of genetic variations (mutations), such as single-base substitutions (or single nucleotide polymorphisms) and small deletions or insertions. These genetic variations can be routinely detected by DHPLC gene scanning at the germ-line and somatic levels. Epigenetic alterations, such as changes in DNA methylation...
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