Article
Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.
Thrombosis and haemostasis - 1 Apr 2003
Maquoi Erik, Demeulemeester Diego, Vörös Gabor, Collen Désire, Lijnen H Roger
Abstract excerpt
To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat diet (HFD) for 15 weeks. MMP-3(-/-) mice were hyperphagic and gained more weight than the MMP-3(+/+) mice. At the time of sacrifice, the body weight of the MMP-3(-/-) mice was significantly higher than that of the...
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