Article
Regulation of attention and response to therapy in dementia by butyrylcholinesterase.
Pharmacogenetics - 1 Apr 2003
O'Brien Kirsty K, Saxby Brian K, Ballard Clive G, Grace Jan, Harrington Frances, Ford Gary A, O'Brien John T, Swan Alan G, Fairbairn Andrew F, Wesnes Keith, del Ser Teodoro, Edwardson James A, Morris Christopher M, McKeith Ian G
Abstract excerpt
OBJECTIVES: To determine the response of patients with different butyrylcholinesterase genotypes to therapy, and the influence of butyrylcholinesterase on cognition. Acetylcholine plays a key role in attention and memory and reduced cortical acetylcholine is associated with the severity of dementia. Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.