Article
Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4.
Molecular and cellular biology - 1 Sept 2005
Utley Rhea T, Lacoste Nicolas, Jobin-Robitaille Olivier, Allard Stéphane, Côté Jacques
Abstract excerpt
The NuA4 complex is a histone H4/H2A acetyltransferase involved in transcription and DNA repair. While histone acetylation is important in many processes, it has become increasingly clear that additional histone modifications also play a crucial interrelated role. To understand how NuA4 action is regulated, we tested various H4 tail peptides harboring known modifications in HAT assays. While dimethylation at...
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