Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development.

Current biology : CB - 10 Jul 2001

Kirby R J, Hamilton G M, Finnegan D J, Johnson K J, Jarman A P

Abstract excerpt

SIX5 belongs to a family of highly conserved homeodomain transcription factors implicated in development and disease. The mammalian SIX5/SIX4 gene pair is likely to be involved in the development of mesodermal structures. Moreover, a variety of data have implicated human SIX5 dysfunction as a contributor to myotonic dystrophy type 1 (DM1), a condition characterized by a number of pathologies including muscle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila Proteins
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Insect Proteins

Share to Muscle, Skeletal

Share to Nerve Tissue Proteins

Share to Testis

Source

Identifiers

PMID: 11470409
DOI: 10.1016/s0960-9822(01)00319-0

Genes

SIX5
SIX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development.PMID 11470409Read ↗

Altered myogenesis in Six1-deficient mice.Semantic proximity Read ↗

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defectsSemantic proximity Read ↗

Six family genes--structure and function as transcription factors and their roles in development.Semantic proximity Read ↗

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.Semantic proximity Read ↗

Developmental regulators drive DUX4 expression in facioscapulohumeral muscular dystrophySemantic proximity Read ↗

Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial DevelopmentSemantic proximity Read ↗

Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1.Semantic proximity Read ↗

Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in MiceSemantic proximity Read ↗

Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity.Semantic proximity Read ↗

The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesisSemantic proximity Read ↗

SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation.Semantic proximity Read ↗

Hybrid sterility-6: a mouse t complex locus controlling sperm flagellar assembly and movement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.