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Article

Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer.

Human molecular genetics - 15 Apr 2003

Lang Deborah, Epstein Jonathan A

Abstract excerpt

The neurocristopathies encompass a spectrum of developmental disorders characterized by abnormalities of neural crest-derived structures. Neural crest cells are pluripotent progenitors and the mechanisms by which specific cell-fate decisions are regulated have emerged as an important field of study. Many neurocristopathies are characterized by defects in melanocyte differentiation that can result in pigmentation...

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Topics

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Share to Enhancer Elements, Genetic
Share to High Mobility Group Proteins
Share to Microphthalmia-Associated Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paired Box Transcription Factors

Share to PAX3 Transcription Factor

Share to Proto-Oncogene Proteins c-ret

Share to Receptor Protein-Tyrosine Kinases

Share to SOXE Transcription Factors

Source

Identifiers

PMID: 12668617
DOI: 10.1093/hmg/ddg107

Genes

RET
MITF
SOX10
PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer.PMID 12668617Read ↗

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SOX transcription factors direct TCF-independent WNT/beta-catenin transcriptionSemantic proximity Read ↗

Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development.Semantic proximity Read ↗

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Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3.Semantic proximity Read ↗

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