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Article

Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3.

Journal of pediatric surgery - 1 Oct 2009

Leon Thomas Y Y, Ngan Elly S W, Poon Hiu-Ching, So Man-Ting, Lui Vincent C H, Tam Paul K H, Garcia-Barcelo Maria Mercedes

Abstract excerpt

BACKGROUND: The rearranged during transfection (RET) gene encodes a single-pass receptor whose proper expression and function are essential for the development of enteric nervous system. Mutations in RET regulatory regions are also associated with Hirschsprung disease (HSCR) (aganglionosis of the...

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Share to Enteric Nervous System
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PAX3 Transcription Factor

Share to Proto-Oncogene Proteins c-ret

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Source

Identifiers

PMID: 19853745
DOI: 10.1016/j.jpedsurg.2008.11.055

Genes

RET
SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19853745-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3.PMID 19853745Read ↗

A gene regulatory network explains RET–EDNRB epistasis in Hirschsprung diseaseSemantic proximity Read ↗

Evaluation of the NK2 homeobox 1 gene (NKX2-1) as a Hirschsprung's disease locus.Semantic proximity Read ↗

HOXB5 cooperates with NKX2-1 in the transcription of human RET.Semantic proximity Read ↗

A multi-enhancer <i>RET</i> regulatory code is disrupted in Hirschsprung diseaseSemantic proximity Read ↗

<i>RET</i> enhancer haplotype-dependent remodeling of the human fetal gut development programSemantic proximity Read ↗

RET enhancer haplotype-dependent remodeling of the human fetal gut development programSemantic proximity Read ↗

Hirschsprung's disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation.Semantic proximity Read ↗

Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression.Semantic proximity Read ↗

The developmental etiology and pathogenesis of Hirschsprung disease.Semantic proximity Read ↗

Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.Semantic proximity Read ↗

Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression.Semantic proximity Read ↗

Combined effects of <i>Ret</i> coding and enhancer loss-of-function alleles cause progressive loss of inhibitory motor neurons in the enteric nervous systemSemantic proximity Read ↗

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