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Article

Pathogenesis of arteriovenous malformations in the absence of endoglin.

Circulation research - 30 Apr 2010

Mahmoud Marwa, Allinson Kathleen R, Zhai Zhenhua, Oakenfull Rachael, Ghandi Pranita, Adams Ralf H, Fruttiger Marcus, Arthur Helen M

Abstract excerpt

RATIONALE: Arteriovenous malformations (AVMs) result in anomalous direct blood flow between arteries and veins, bypassing the normal capillary bed. Depending on size and location, AVMs may lead to severe clinical effects including systemic cyanosis (pulmonary AVMs), hemorrhagic stroke (cerebral AVMs) and high output cardiac failure (hepatic AVMs). The factors leading to AVM formation are poorly understood, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20224041
DOI: 10.1161/CIRCRESAHA.109.211037

Genes

ACVRL1
ENG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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