Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alendronate affects long bone length and growth plate morphology in the oim mouse model for Osteogenesis Imperfecta.

Bone - 1 Mar 2003

Evans K D, Lau S T, Oberbauer A M, Martin R B

Abstract excerpt

Alendronate, a bisphosphonate drug, has shown promise in reducing remodeling and bone loss in postmenopausal osteoporosis. Alendronate acts directly on the osteoclast, inhibiting its resorption capability. This inhibition of osteoclast activity has led to the use of bisphosphonates in the treatment of the osteogenesis imperfecta condition. Treatment of osteogenesis imperfecta with bisphosphonates enhances bone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Development
Share to Disease Models, Animal
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Growth Plate

Share to Mice, Mutant Strains

Share to Osteogenesis Imperfecta

Source

Identifiers

PMID: 12667554
DOI: 10.1016/s8756-3282(02)00974-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alendronate affects long bone length and growth plate morphology in the oim mouse model for Osteogenesis Imperfecta.PMID 12667554Read ↗

Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.Semantic proximity Read ↗

Effect of bisphosphonates on the rapidly growing male murine skeleton.Semantic proximity Read ↗

Sclerostin-Antibody Treatment Decreases Fracture Rates in Axial Skeleton and Improves the Skeletal Phenotype in Growing oim/oim Mice.Semantic proximity Read ↗

Fracture healing with alendronate treatment in the Brtl/+ mouse model of osteogenesis imperfecta.Semantic proximity Read ↗

Differential aging of growth plate cartilage underlies differences in bone length and thus helps determine skeletal proportionsSemantic proximity Read ↗

Craniofacial allometry in the OIM-/- mouse model of osteogenesis imperfecta.Semantic proximity Read ↗

Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis ImperfectaSemantic proximity Read ↗

Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in miceSemantic proximity Read ↗

Toward an understanding of the short bone phenotype associated with multiple osteochondromas.Semantic proximity Read ↗

Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient miceSemantic proximity Read ↗

Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim).Semantic proximity Read ↗

Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.